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BMCBI
2011
12 years 11 months ago
Context-dependent transcriptional regulations between signal transduction pathways
Background: Cells coordinate their metabolism, proliferation, and cellular communication according to environmental cues through signal transduction. Because signal transduction h...
Sohyun Hwang, Sangwoo Kim, Heesung Shin, Doheon Le...
BMCBI
2005
114views more  BMCBI 2005»
13 years 4 months ago
Signal transduction pathway profiling of individual tumor samples
Background: Signal transduction pathways convey information from the outside of the cell to transcription factors, which in turn regulate gene expression. Our objective is to anal...
Thomas Breslin, Morten Krogh, Carsten Peterson, Ca...
BIOSYSTEMS
2007
175views more  BIOSYSTEMS 2007»
13 years 4 months ago
Alternative routes and mutational robustness in complex regulatory networks
Alternative pathways through a gene regulation network connect a regulatory molecule to its (indirect) regulatory target via different intermediate regulators. We here show for tw...
Andreas Wagner, Jeremiah Wright
BMCBI
2006
169views more  BMCBI 2006»
13 years 4 months ago
Beyond microarrays: Finding key transcription factors controlling signal transduction pathways
Background: Massive gene expression changes in different cellular states measured by microarrays, in fact, reflect just an "echo" of real molecular processes in the cell...
Alexander E. Kel, Nico Voss, Ruy Jauregui, Olga V....
BMCBI
2006
133views more  BMCBI 2006»
13 years 4 months ago
Topological basis of signal integration in the transcriptional-regulatory network of the yeast, Saccharomyces cerevisiae
Background: Signal recognition and information processing is a fundamental cellular function, which in part involves comprehensive transcriptional regulatory (TR) mechanisms carri...
Illés J. Farkas, Chuang Wu, Chakra Chennubh...