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BMCBI
2010
167views more  BMCBI 2010»
13 years 5 months ago
Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies
Background: Knowledge of transcription factor-DNA binding patterns is crucial for understanding gene transcription. Numerous DNA-binding proteins are annotated as transcription fa...
Denitsa Alamanova, Philip Stegmaier, Alexander E. ...
BMCBI
2010
240views more  BMCBI 2010»
13 years 5 months ago
TAM: A method for enrichment and depletion analysis of a microRNA category in a list of microRNAs
Background: MicroRNAs (miRNAs) are a class of important gene regulators. The number of identified miRNAs has been increasing dramatically in recent years. An emerging major challe...
Ming Lu, Bing Shi, Juan Wang, Qun Cao, Qinghua Cui
BMCBI
2007
167views more  BMCBI 2007»
13 years 5 months ago
AlzPharm: integration of neurodegeneration data using RDF
Background: Neuroscientists often need to access a wide range of data sets distributed over the Internet. These data sets, however, are typically neither integrated nor interopera...
Hugo Y. K. Lam, Luis N. Marenco, Tim Clark, Yong G...
BMCBI
2011
13 years 5 days ago
Learning genetic epistasis using Bayesian network scoring criteria
Background: Gene-gene epistatic interactions likely play an important role in the genetic basis of many common diseases. Recently, machine-learning and data mining methods have be...
Xia Jiang, Richard E. Neapolitan, M. Michael Barma...