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» DNA Motif Representation with Nucleotide Dependency
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TCBB
2008
103views more  TCBB 2008»
13 years 4 months ago
DNA Motif Representation with Nucleotide Dependency
The problem of discovering novel motifs of binding sites is important to the understanding of gene regulatory networks. Motifs are generally represented by matrices (PWM or PSSM) o...
Francis Y. L. Chin, Henry C. M. Leung
APBC
2008
231views Bioinformatics» more  APBC 2008»
13 years 6 months ago
Optimal Algorithm for Finding DNA Motifs with Nucleotide Adjacent Dependency
: Finding motifs and the corresponding binding sites is a critical and challenging problem in studying the process of gene expression. String and matrix representations are two pop...
Francis Y. L. Chin, Henry C. M. Leung, Man-Hung Si...
GECCO
2005
Springer
124views Optimization» more  GECCO 2005»
13 years 10 months ago
The evolutionary computation approach to motif discovery in biological sequences
Finding motifs — patterns of conserved residues — within nucleotide and protein sequences is a key part of understanding function and regulation within biological systems. Thi...
Michael A. Lones, Andrew M. Tyrrell
BMCBI
2010
126views more  BMCBI 2010»
13 years 4 months ago
Antisense DNA parameters derived from next-nearest-neighbor analysis of experimental data
Background: The enumeration of tetrameric and other sequence motifs that are positively or negatively correlated with in vivo antisense DNA effects has been a useful addition to t...
Donald M. Gray, Carla W. Gray, Byong-Hoon Yoo, Tzu...
RECOMB
2003
Springer
14 years 4 months ago
Modeling dependencies in protein-DNA binding sites
The availability of whole genome sequences and high-throughput genomic assays opens the door for in silico analysis of transcription regulation. This includes methods for discover...
Yoseph Barash, Gal Elidan, Nir Friedman, Tommy Kap...