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BMCBI
2006
108views more  BMCBI 2006»
13 years 6 months ago
Promoter prediction and annotation of microbial genomes based on DNA sequence and structural responses to superhelical stress
Background: In our previous studies, we found that the sites in prokaryotic genomes which are most susceptible to duplex destabilization under the negative superhelical stresses t...
Huiquan Wang, Craig J. Benham
ISBI
2006
IEEE
14 years 6 months ago
Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort
We present a fully-automated technique for visualizing localized cerebral ventricle shape differences between large clinical subject groups who have received a magnetic resonance ...
Owen T. Carmichael, Paul M. Thompson, Rebecca A. D...
BMCBI
2010
154views more  BMCBI 2010»
13 years 6 months ago
Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data
Background: A major goal of molecular biology is determining the mechanisms that control the transcription of genes. Motif Enrichment Analysis (MEA) seeks to determine which DNA-b...
Robert C. McLeay, Timothy L. Bailey
KDD
2007
ACM
136views Data Mining» more  KDD 2007»
14 years 6 months ago
Information genealogy: uncovering the flow of ideas in non-hyperlinked document databases
We now have incrementally-grown databases of text documents ranging back for over a decade in areas ranging from personal email, to news-articles and conference proceedings. While...
Benyah Shaparenko, Thorsten Joachims
IISWC
2009
IEEE
14 years 21 days ago
Experimental evaluation of N-tier systems: Observation and analysis of multi-bottlenecks
In many areas such as e-commerce, mission-critical N-tier applications have grown increasingly complex. They are characterized by non-stationary workloads (e.g., peak load several...
Simon Malkowski, Markus Hedwig, Calton Pu