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» Drug Discovery on Cluster Farms
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BMCBI
2010
132views more  BMCBI 2010»
13 years 5 months ago
Protein network prediction and topological analysis in Leishmania major as a tool for drug target selection
Background: Leishmaniasis is a virulent parasitic infection that causes a worldwide disease burden. Most treatments have toxic side-effects and efficacy has decreased due to the e...
Andrés F. Flórez, Daeui Park, Jong B...
BMCBI
2008
118views more  BMCBI 2008»
13 years 5 months ago
DOVIS: an implementation for high-throughput virtual screening using AutoDock
Background: Molecular-docking-based virtual screening is an important tool in drug discovery that is used to significantly reduce the number of possible chemical compounds to be i...
Shuxing Zhang, Kamal Kumar, Xiaohui Jiang, Anders ...
BMCBI
2007
123views more  BMCBI 2007»
13 years 5 months ago
Heritable clustering and pathway discovery in breast cancer integrating epigenetic and phenotypic data
Background: In order to recapitulate tumor progression pathways using epigenetic data, we developed novel clustering and pathway reconstruction algorithms, collectively referred t...
Zailong Wang, Pearlly Yan, Dustin P. Potter, Chari...
NIPS
2004
13 years 7 months ago
Detecting Significant Multidimensional Spatial Clusters
Assume a uniform, multidimensional grid of bivariate data, where each cell of the grid has a count ci and a baseline bi. Our goal is to find spatial regions (d-dimensional rectang...
Daniel B. Neill, Andrew W. Moore, Francisco Pereir...
CAMP
2005
IEEE
13 years 11 months ago
Virtual Astronomy, Information Technology, and the New Scientific Methodology
—All sciences, including astronomy, are now entering the era of information abundance. The exponentially increasing volume and complexity of modern data sets promises to transfor...
S. George Djorgovski