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BIOINFORMATICS
2006
13 years 5 months ago
2006
Motivation: Over 50% of human genes contain CpG islands in their 5'-regions. Methylation patterns of CpG islands are involved in tissue-specific gene expression and regulatio...
BMCBI
2008
13 years 5 months ago
2008
Background: Multivariate ordination methods are powerful tools for the exploration of complex data structures present in microarray data. These methods have several advantages com...
BMCBI
2005
13 years 5 months ago
2005
Background: There are currently a number of competing techniques for low-level processing of oligonucleotide array data. The choice of technique has a profound effect on subsequen...
BMCBI
2004
13 years 5 months ago
2004
Background: When DNA microarray data are used for gene clustering, genotype/phenotype correlation studies, or tissue classification the signal intensities are usually transformed ...
BMCBI
2011
13 years 9 days ago
2011
Background: Discovery of biomarkers that are correlated with therapy response and thus with survival is an important goal of medical research on severe diseases, e.g. cancer. Freq...