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BMCBI
2010
190views more  BMCBI 2010»
13 years 6 months ago
APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility
Background: It is well known that most of the binding free energy of protein interaction is contributed by a few key hot spot residues. These residues are crucial for understandin...
Jun-Feng Xia, Xing-Ming Zhao, Jiangning Song, De-S...
BMCBI
2010
137views more  BMCBI 2010»
13 years 6 months ago
Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments
Background: While the pairwise alignments produced by sequence similarity searches are a powerful tool for identifying homologous proteins - proteins that share a common ancestor ...
Michael L. Sierk, Michael E. Smoot, Ellen J. Bass,...
BMCBI
2010
98views more  BMCBI 2010»
13 years 6 months ago
Learning to predict expression efficacy of vectors in recombinant protein production
Background: Recombinant protein production is a useful biotechnology to produce a large quantity of highly soluble proteins. Currently, the most widely used production system is t...
Wen-Ching Chan, Po-Huang Liang, Yan-Ping Shih, Uen...
BMCBI
2006
152views more  BMCBI 2006»
13 years 6 months ago
A two-stage approach for improved prediction of residue contact maps
Background: Protein topology representations such as residue contact maps are an important intermediate step towards ab initio prediction of protein structure. Although improvemen...
Alessandro Vullo, Ian Walsh, Gianluca Pollastri
BMCBI
2006
159views more  BMCBI 2006»
13 years 6 months ago
EVEREST: automatic identification and classification of protein domains in all protein sequences
Background: Proteins are comprised of one or several building blocks, known as domains. Such domains can be classified into families according to their evolutionary origin. Wherea...
Elon Portugaly, Amir Harel, Nathan Linial, Michal ...