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» Estimating p-values in small microarray experiments
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BMCBI
2010
132views more  BMCBI 2010»
13 years 4 months ago
Parallel multiplicity and error discovery rate (EDR) in microarray experiments
Background: In microarray gene expression profiling experiments, differentially expressed genes (DEGs) are detected from among tens of thousands of genes on an array using statist...
Wayne Wenzhong Xu, Clay J. Carter
BMCBI
2010
181views more  BMCBI 2010»
13 years 4 months ago
Intensity dependent estimation of noise in microarrays improves detection of differentially expressed genes
Background: In many microarray experiments, analysis is severely hindered by a major difficulty: the small number of samples for which expression data has been measured. When one ...
Amit Zeisel, Amnon Amir, Wolfgang J. Köstler,...
BIOINFORMATICS
2005
72views more  BIOINFORMATICS 2005»
13 years 4 months ago
Use of within-array replicate spots for assessing differential expression in microarray experiments
Motivation. Spotted arrays are often printed with probes in duplicate or triplicate, but current methods for assessing differential expression are not able to make full use of the...
Gordon K. Smyth, Joëlle Michaud, Hamish S. Sc...
BMCBI
2010
91views more  BMCBI 2010»
13 years 3 months ago
Washing scaling of GeneChip microarray expression
Background: Post-hybridization washing is an essential part of microarray experiments. Both the quality of the experimental washing protocol and adequate consideration of washing ...
Hans Binder, Knut Krohn, Conrad J. Burden
BMCBI
2010
80views more  BMCBI 2010»
13 years 4 months ago
Power and sample size estimation in microarray studies
Background: Before conducting a microarray experiment, one important issue that needs to be determined is the number of arrays required in order to have adequate power to identify...
Wei-Jiun Lin, Huey-miin Hsueh, James J. Chen