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» Evolutionary computation: a unified approach
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BMCBI
2010
118views more  BMCBI 2010»
13 years 5 months ago
Towards realistic benchmarks for multiple alignments of non-coding sequences
Background: With the continued development of new computational tools for multiple sequence alignment, it is necessary today to develop benchmarks that aid the selection of the mo...
Jaebum Kim, Saurabh Sinha
BMCBI
2010
189views more  BMCBI 2010»
13 years 5 months ago
High quality protein sequence alignment by combining structural profile prediction and profile alignment using SABERTOOTH
Background: Protein alignments are an essential tool for many bioinformatics analyses. While sequence alignments are accurate for proteins of high sequence similarity, they become...
Florian Teichert, Jonas Minning, Ugo Bastolla, Mar...
GPEM
2008
128views more  GPEM 2008»
13 years 5 months ago
Coevolutionary bid-based genetic programming for problem decomposition in classification
In this work a cooperative, bid-based, model for problem decomposition is proposed with application to discrete action domains such as classification. This represents a significan...
Peter Lichodzijewski, Malcolm I. Heywood
JCB
2006
107views more  JCB 2006»
13 years 5 months ago
Maximum Likelihood Molecular Clock Comb: Analytic Solutions
Maximum likelihood (ML) is increasingly used as an optimality criterion for selecting evolutionary trees, but finding the global optimum is a hard computational task. Because no g...
Benny Chor, Amit Khetan, Sagi Snir
BMCBI
2005
162views more  BMCBI 2005»
13 years 5 months ago
Accelerated probabilistic inference of RNA structure evolution
Background: Pairwise stochastic context-free grammars (Pair SCFGs) are powerful tools for evolutionary analysis of RNA, including simultaneous RNA sequence alignment and secondary...
Ian Holmes