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» Functional Classification of G-Protein Coupled Receptors, Ba...
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EVOW
2006
Springer
13 years 8 months ago
Functional Classification of G-Protein Coupled Receptors, Based on Their Specific Ligand Coupling Patterns
Functional identification of G-Protein Coupled Receptors (GPCRs) is one of the current focus areas of pharmaceutical research. Although thousands of GPCR sequences are known, many ...
Burcu Bakir, Osman Ugur Sezerman
BMCBI
2004
101views more  BMCBI 2004»
13 years 4 months ago
A database for G proteins and their interaction with GPCRs
Background: G protein-coupled receptors (GPCRs) transduce signals from extracellular space into the cell, through their interaction with G proteins, which act as switches forming ...
Antigoni L. Elefsinioti, Pantelis G. Bagos, Ioanni...
BMCBI
2005
141views more  BMCBI 2005»
13 years 4 months ago
A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models
Background: G- Protein coupled receptors (GPCRs) comprise the largest group of eukaryotic cell surface receptors with great pharmacological interest. A broad range of native ligan...
Nikolaos G. Sgourakis, Pantelis G. Bagos, Panagiot...
BMCBI
2007
130views more  BMCBI 2007»
13 years 4 months ago
HMM-ModE - Improved classification using profile hidden Markov models by optimising the discrimination threshold and modifying e
Background: Profile Hidden Markov Models (HMM) are statistical representations of protein families derived from patterns of sequence conservation in multiple alignments and have b...
Prashant K. Srivastava, Dhwani K. Desai, Soumyadee...