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IJCAI
1989
13 years 6 months ago
Functional Representation of Designs and Redesign Problem Solving
gn problem can be abstractly characterized as a constrained function-to-structure mapping. The de­ sign task takes as input the specifications of the desired functions of a device...
Ashok K. Goel, B. Chandrasekaran
BIOINFORMATICS
2008
119views more  BIOINFORMATICS 2008»
13 years 5 months ago
Optimal design of thermally stable proteins
Motivation: For many biotechnological purposes, it is desirable to redesign proteins to be more structurally and functionally stable at higher temperatures. For example, chemical ...
Ryan M. Bannen, Vanitha Suresh, George N. Phillips...
GECCO
2005
Springer
119views Optimization» more  GECCO 2005»
13 years 10 months ago
A multi-objective evolutionary approach to peptide structure redesign and stabilization
The prediction of the native structures of proteins, the socalled protein folding problem, is a NP hard multi-minima optimization problem for which to date no routine solutions ex...
Tim Hohm, Daniel Hoffmann
JAIR
2006
122views more  JAIR 2006»
13 years 5 months ago
Solving Factored MDPs with Hybrid State and Action Variables
Efficient representations and solutions for large decision problems with continuous and discrete variables are among the most important challenges faced by the designers of automa...
Branislav Kveton, Milos Hauskrecht, Carlos Guestri...
JASIS
1998
80views more  JASIS 1998»
13 years 4 months ago
A Distributed Representation Approach to Group Problem Solving
This article develops a theoretical framework of distributed representations to explore the representational properties in group problem solving. The basic principle of distribute...
Jiajie Zhang