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BMCBI
2008
135views more  BMCBI 2008»
13 years 6 months ago
Knowledge-guided multi-scale independent component analysis for biomarker identification
Background: Many statistical methods have been proposed to identify disease biomarkers from gene expression profiles. However, from gene expression profile data alone, statistical...
Li Chen, Jianhua Xuan, Chen Wang, Ie-Ming Shih, Yu...
BMCBI
2010
148views more  BMCBI 2010»
13 years 6 months ago
Structuring heterogeneous biological information using fuzzy clustering of k-partite graphs
Background: Extensive and automated data integration in bioinformatics facilitates the construction of large, complex biological networks. However, the challenge lies in the inter...
Mara L. Hartsperger, Florian Blöchl, Volker S...
BMCBI
2008
226views more  BMCBI 2008»
13 years 6 months ago
ProteoLens: a visual analytic tool for multi-scale database-driven biological network data mining
Background: New systems biology studies require researchers to understand how interplay among myriads of biomolecular entities is orchestrated in order to achieve high-level cellu...
Tianxiao Huan, Andrey Y. Sivachenko, Scott H. Harr...
BMCBI
2010
165views more  BMCBI 2010»
13 years 6 months ago
Bayesian integrated modeling of expression data: a case study on RhoG
Background: DNA microarrays provide an efficient method for measuring activity of genes in parallel and even covering all the known transcripts of an organism on a single array. T...
Rashi Gupta, Dario Greco, Petri Auvinen, Elja Arja...
IJON
2008
128views more  IJON 2008»
13 years 6 months ago
Independent arrays or independent time courses for gene expression time series data analysis
In this paper we apply three different independent component analysis (ICA) methods, including spatial ICA (sICA), temporal ICA (tICA), and spatiotemporal ICA (stICA), to gene exp...
Sookjeong Kim, Jong Kyoung Kim, Seungjin Choi