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» GP challenge: evolving energy function for protein structure...
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BMCBI
2010
116views more  BMCBI 2010»
13 years 5 months ago
A hybrid approach to protein folding problem integrating constraint programming with local search
Background: The protein folding problem remains one of the most challenging open problems in computational biology. Simplified models in terms of lattice structure and energy func...
Abu Zafer M. Dayem Ullah, Kathleen Steinhöfel
BMCBI
2007
94views more  BMCBI 2007»
13 years 5 months ago
A structural analysis of in vitro catalytic activities of hammerhead ribozymes
Background: Ribozymes are small catalytic RNAs that possess the dual functions of sequencespecific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit...
Yu Shao, Susan Wu, Chi Yu Chan, Jessie R. Klapper,...
GECCO
2007
Springer
211views Optimization» more  GECCO 2007»
13 years 11 months ago
An extremal optimization search method for the protein folding problem: the go-model example
The protein folding problem consists of predicting the functional (native) structure of the protein given its linear sequence of amino acids. Despite extensive progress made in un...
Alena Shmygelska