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BMCBI
2006
122views more  BMCBI 2006»
13 years 5 months ago
A multivariate prediction model for microarray cross-hybridization
Background: Expression microarray analysis is one of the most popular molecular diagnostic techniques in the post-genomic era. However, this technique faces the fundamental proble...
Yian A. Chen, Cheng-Chung Chou, Xinghua Lu, Elizab...
BMCBI
2006
127views more  BMCBI 2006»
13 years 5 months ago
PathogenMIPer: a tool for the design of molecular inversion probes to detect multiple pathogens
Background: Here we describe PathogenMIPer, a software program for designing molecular inversion probe (MIP) oligonucleotides for use in pathogen identification and detection. The...
Sreedevi Thiyagarajan, Miloslav Karhanek, Michael ...
BMCBI
2007
127views more  BMCBI 2007»
13 years 5 months ago
Predicting the phenotypic effects of non-synonymous single nucleotide polymorphisms based on support vector machines
Background: Human genetic variations primarily result from single nucleotide polymorphisms (SNPs) that occur approximately every 1000 bases in the overall human population. The no...
Jian Tian, Ningfeng Wu, Xuexia Guo, Jun Guo, Juhua...
JDCTA
2010
159views more  JDCTA 2010»
13 years 17 days ago
QSPR Study Of Mineral Crystal Lattice Energy Based On Gene Expression Programming
In this study, gene expression programming (GEP), a novel genetic algorithm, is used to develop quantitative model as potential screening mechanism for mineral crystal lattice ene...
Yuntao Zhang, Wenbin Dai, Zhengjun Cheng
GECCO
2006
Springer
172views Optimization» more  GECCO 2006»
13 years 9 months ago
Multi-objective optimisation of the protein-ligand docking problem in drug discovery
The pharmaceutical industry is facing an ever-increasing demand to discover novel drugs that are more effective and safer than existing ones. The industry faces huge problem in im...
A. Oduguwa, A. Tiwari, S. Fiorentino, R. Roy