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» Globally, unrelated protein sequences appear random
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BIOINFORMATICS
2010
94views more  BIOINFORMATICS 2010»
13 years 5 months ago
Globally, unrelated protein sequences appear random
Motivation: To test whether protein folding constraints and secondary structure sequence preferences significantly reduce the space of amino acid words in proteins, we compared th...
Daniel T. Lavelle, William R. Pearson
BMCBI
2005
115views more  BMCBI 2005»
13 years 5 months ago
Statistical distributions of optimal global alignment scores of random protein sequences
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Hongxia Pang, Jiaowei Tang, Su-Shing Chen, Shiheng...
BMCBI
2010
124views more  BMCBI 2010»
13 years 5 months ago
Estimation and efficient computation of the true probability of recurrence of short linear protein sequence motifs in unrelated
Background: Large datasets of protein interactions provide a rich resource for the discovery of Short Linear Motifs (SLiMs) that recur in unrelated proteins. However, existing met...
Norman E. Davey, Richard J. Edwards, Denis C. Shie...
BMCBI
2007
114views more  BMCBI 2007»
13 years 5 months ago
False occurrences of functional motifs in protein sequences highlight evolutionary constraints
Background: False occurrences of functional motifs in protein sequences can be considered as random events due solely to the sequence composition of a proteome. Here we use a nume...
Allegra Via, Pier Federico Gherardini, Enrico Ferr...
AUSDM
2006
Springer
144views Data Mining» more  AUSDM 2006»
13 years 9 months ago
Mining Quantitative Association Rules in Protein Sequences
Abstract. Lot of research has gone into understanding the composition and nature of proteins, still many things remain to be understood satisfactorily. It is now generally believed...
Nitin Gupta, Nitin Mangal, Kamal Tiwari, Pabitra M...