6 search results - page 1 / 2 » HAPSIMU: a genetic simulation platform for population-based ... |
BMCBI
2008
13 years 5 months ago
2008
Background: Population structure is an important cause leading to inconsistent results in population-based association studies (PBAS) of human diseases. Various statistical method...
BMCBI
2011
12 years 8 months ago
2011
Background: The cost efficient two-stage design is often used in genome-wide association studies (GWASs) in searching for genetic loci underlying the susceptibility for complex di...
BMCBI
2005
13 years 4 months ago
2005
Background: Good statistical models for analyzing and simulating multilocus recombination data exist but are not accessible to many biologists because their use requires reasonabl...
BMCBI
2008
13 years 5 months ago
2008
Background: Correctly merged data sets that have been independently genotyped can increase statistical power in linkage and association studies. However, alleles from microsatelli...
NAR
2011
12 years 11 months ago
2011
Numerous genetic variations have been found to be related to human diseases. Significant portion of those affect the drug response as well by changing the protein structure and fu...