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» Hardness Results for Homology Localization
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BMCBI
2011
13 years 8 days ago
Accurate statistics for local sequence alignment with position-dependent scoring by rare-event sampling
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
Stefan Wolfsheimer, Inke Herms, Sven Rahmann, Alex...
BMCBI
2008
106views more  BMCBI 2008»
13 years 5 months ago
Searching for evolutionary distant RNA homologs within genomic sequences using partition function posterior probabilities
Background: Identification of RNA homologs within genomic stretches is difficult when pairwise sequence identity is low or unalignable flanking residues are present. In both cases...
Usman Roshan, Satish Chikkagoudar, Dennis R. Lives...
BMCBI
2006
120views more  BMCBI 2006»
13 years 5 months ago
Optimizing amino acid substitution matrices with a local alignment kernel
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...
Hiroto Saigo, Jean-Philippe Vert, Tatsuya Akutsu
BMCBI
2006
143views more  BMCBI 2006»
13 years 5 months ago
Fast estimation of the difference between two PAM/JTT evolutionary distances in triplets of homologous sequences
Background: The estimation of the difference between two evolutionary distances within a triplet of homologs is a common operation that is used for example to determine which of t...
Christophe Dessimoz, Manuel Gil, Adrian Schneider,...
COMPGEOM
2009
ACM
13 years 11 months ago
Zigzag persistent homology and real-valued functions
We study the problem of computing zigzag persistence of a sequence of homology groups and study a particular sequence derived from the levelsets of a real-valued function on a top...
Gunnar Carlsson, Vin de Silva, Dmitriy Morozov