Alternative splicing is one of the most important mechanisms to generate a large number of mRNA and protein isoforms from a small number of genes. Its study became one of the hot ...
Background: Most human genes produce several transcripts with different exon contents by using alternative promoters, alternative polyadenylation sites and alternative splice site...
Pierre de la Grange, Martin Dutertre, Margot Corre...
Background: The Affymetrix™ technology is nowadays a well-established method for the analysis of gene expression profiles in cancer research studies. However, changes in gene ex...
Davide Rambaldi, Barbara Felice, Viviane Praz, Phi...
Background: The p53 gene family consists of the three genes p53, p63 and p73, which have polyhedral non-overlapping functions in pivotal cellular processes such as DNA synthesis a...
Background: An important challenge in eukaryotic gene prediction is accurate identification of alternatively spliced exons. Functional transcripts can go undetected in gene expres...