21 search results - page 1 / 5 » Improved human disease candidate gene prioritization using m... |
BMCBI
2007
13 years 4 months ago
2007
Background: The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors. High-thro...
BMCBI
2008
13 years 4 months ago
2008
Background: Genes that are co-expressed tend to be involved in the same biological process. However, co-expression is not a very reliable predictor of functional links between gen...
BMCBI
2005
13 years 4 months ago
2005
Background: Regions of interest identified through genetic linkage studies regularly exceed 30 centimorgans in size and can contain hundreds of genes. Traditionally this number is...
BMCBI
2008
13 years 4 months ago
2008
Background: Millions of single nucleotide polymorphisms have been identified as a result of the human genome project and the rapid advance of high throughput genotyping technology...
BMCBI
2010
13 years 4 months ago
2010
Background: Discovering novel disease genes is still challenging for diseases for which no prior knowledge - such as known disease genes or disease-related pathways - is available...