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» Including Biological Literature Improves Homology Search
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BMCBI
2002
110views more  BMCBI 2002»
13 years 5 months ago
Identifying functional relationships among human genes by systematic analysis of biological literature
Background: The availability of biomedical literature in electronic format has made it possible to implement automatic text processing methods to expose implicit relationships amo...
Yong-Chuan Tao, Rudolph L. Leibel
BMCBI
2010
101views more  BMCBI 2010»
13 years 5 months ago
Enrichment of homologs in insignificant BLAST hits by co-complex network alignment
Background: Homology is a crucial concept in comparative genomics. The algorithm probably most widely used for homology detection in comparative genomics, is BLAST. Usually a stri...
Like Fokkens, Sandra M. C. Botelho, Jos Boekhorst,...
BMCBI
2007
142views more  BMCBI 2007»
13 years 5 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
BMCBI
2007
144views more  BMCBI 2007»
13 years 5 months ago
Motif kernel generated by genetic programming improves remote homology and fold detection
Background: Protein remote homology detection is a central problem in computational biology. Most recent methods train support vector machines to discriminate between related and ...
Tony Håndstad, Arne J. H. Hestnes, Pål...
BMCBI
2006
144views more  BMCBI 2006»
13 years 5 months ago
ProFAT: a web-based tool for the functional annotation of protein sequences
Background: The functional annotation of proteins relies on published information concerning their close and remote homologues in sequence databases. Evidence for remote sequence ...
Charles Richard Bradshaw, Vineeth Surendranath, Bi...