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BMCBI
2011
13 years 1 months ago
CODA (CrossOver Distribution Analyzer): quantitative characterization of crossover position patterns along chromosomes
Background: During meiosis, homologous chromosomes exchange segments via the formation of crossovers. This phenomenon is highly regulated; in particular, crossovers are distribute...
Franck Gauthier, Olivier C. Martin, Matthieu Falqu...
NAR
2008
119views more  NAR 2008»
13 years 6 months ago
MALISAM: a database of structurally analogous motifs in proteins
MALISAM (manual alignments for structurally analogous motifs) represents the first database containing pairs of structural analogs and their alignments. To find reliable analogs, ...
Hua Cheng, Bong-Hyun Kim, Nick V. Grishin
BMCBI
2010
137views more  BMCBI 2010»
13 years 6 months ago
Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments
Background: While the pairwise alignments produced by sequence similarity searches are a powerful tool for identifying homologous proteins - proteins that share a common ancestor ...
Michael L. Sierk, Michael E. Smoot, Ellen J. Bass,...
BMCBI
2010
121views more  BMCBI 2010»
13 years 6 months ago
Knowledge-based annotation of small molecule binding sites in proteins
Background: The study of protein-small molecule interactions is vital for understanding protein function and for practical applications in drug discovery. To benefit from the rapi...
Ratna R. Thangudu, Manoj Tyagi, Benjamin A. Shoema...
BMCBI
2006
112views more  BMCBI 2006»
13 years 6 months ago
A phylogenomic gene cluster resource: the Phylogenetically Inferred Groups (PhIGs) database
Background: We present here the PhIGs database, a phylogenomic resource for sequenced genomes. Although many methods exist for clustering gene families, very few attempt to create...
Paramvir S. Dehal, Jeffrey L. Boore