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BIOINFORMATICS
2005
152views more  BIOINFORMATICS 2005»
13 years 4 months ago
Intervention in context-sensitive probabilistic Boolean networks
Motivation: Intervention in a gene regulatory network is used to help it avoid undesirable states, such as those associated with a disease. Several types of intervention have been...
Ranadip Pal, Aniruddha Datta, Michael L. Bittner, ...
TSP
2008
132views more  TSP 2008»
13 years 4 months ago
Robust Intervention in Probabilistic Boolean Networks
Probabilistic Boolean networks (PBNs) have been recently introduced as a paradigm for modeling genetic regulatory networks. One of the objectives of PBN modeling is to use the netw...
Ranadip Pal, Aniruddha Datta, Edward R. Dougherty
BIOINFORMATICS
2006
142views more  BIOINFORMATICS 2006»
13 years 4 months ago
Intervention in a family of Boolean networks
Motivation: Intervention in a gene regulatory network is used to avoid undesirable states, such as those associated with a disease. Several types of intervention have been studied...
Ashish Choudhary, Aniruddha Datta, Michael L. Bitt...
GECCO
2006
Springer
172views Optimization» more  GECCO 2006»
13 years 8 months ago
Evolving boolean networks to find intervention points in dengue pathogenesis
We use probabilistic boolean networks to simulate the pathogenesis of Dengue Hemorraghic Fever (DHF). Based on Chaturvedi's work, the strength of cytokine influences are mode...
Philip Tan, Joc Cing Tay
TSP
2008
134views more  TSP 2008»
13 years 3 months ago
Effect of Function Perturbation on the Steady-State Distribution of Genetic Regulatory Networks: Optimal Structural Intervention
Abstract--The dynamics of a rule-based gene regulatory network are determined by the regulatory functions in conjunction with whatever probability distributions are involved in net...
Xiaoning Qian, Edward R. Dougherty