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BIOINFORMATICS
2011
12 years 11 months ago
Inverse perturbation for optimal intervention in gene regulatory networks
Motivation: Analysis and intervention in the dynamics of gene regulatory networks is at the heart of emerging efforts in the development of modern treatment of numerous ailments i...
Nidhal Bouaynaya, Roman Shterenberg, Dan Schonfeld
TSP
2008
134views more  TSP 2008»
13 years 3 months ago
Effect of Function Perturbation on the Steady-State Distribution of Genetic Regulatory Networks: Optimal Structural Intervention
Abstract--The dynamics of a rule-based gene regulatory network are determined by the regulatory functions in conjunction with whatever probability distributions are involved in net...
Xiaoning Qian, Edward R. Dougherty
BIOINFORMATICS
2005
152views more  BIOINFORMATICS 2005»
13 years 4 months ago
Intervention in context-sensitive probabilistic Boolean networks
Motivation: Intervention in a gene regulatory network is used to help it avoid undesirable states, such as those associated with a disease. Several types of intervention have been...
Ranadip Pal, Aniruddha Datta, Michael L. Bittner, ...
BIOINFORMATICS
2006
142views more  BIOINFORMATICS 2006»
13 years 4 months ago
Intervention in a family of Boolean networks
Motivation: Intervention in a gene regulatory network is used to avoid undesirable states, such as those associated with a disease. Several types of intervention have been studied...
Ashish Choudhary, Aniruddha Datta, Michael L. Bitt...
GECCO
2008
Springer
179views Optimization» more  GECCO 2008»
13 years 5 months ago
Evolution of discrete gene regulatory models
Gene regulatory networks (GRNs) are complex control systems that govern the interaction of genes, which ultimately control cellular processes at the protein level. GRNs can be ted...
Afshin Esmaeili, Christian Jacob