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JCNS
2002
62views more  JCNS 2002»
13 years 5 months ago
Computing Transient Gating Charge Movement of Voltage-Dependent Ion Channels
The opening of voltage-gated sodium, potassium, and calcium ion channels has a steep relationship with voltage. In response to changes in the transmembrane voltage, structural move...
Anthony Varghese, Linda M. Boland
TCBB
2011
13 years 12 days ago
Semi-Markov Models for Brownian Dynamics Permeation in Biological Ion Channels
—Constructing accurate computational models that explain how ions permeate through a biological ion channel is an important problem in biophysics and drug design. Brownian dynami...
Vikram Krishnamurthy, Kai Yiu Luk
WSC
1998
13 years 6 months ago
Modeling Cardiac Ion Channel Conductivity: Model Fitting via Simulation
We describe a Markov state model for a cloned potassium channel of the human heart ( 1KvLQTI ). The parameters of the model are determined by a least-squares fit of predicted vs. ...
John L. Maryak, Richard H. Smith, Raimond L. Winsl...
TSP
2008
106views more  TSP 2008»
13 years 5 months ago
An EM Algorithm for Ion-Channel Current Estimation
Parameter estimation of a continuous-time Markov chain observed through a discrete-time memoryless channel is studied. An expectation-maximization (EM) algorithm for maximum likeli...
William J. J. Roberts, Yariv Ephraim
ICANN
2009
Springer
14 years 21 hour ago
Acquiring and Classifying Signals from Nanopores and Ion-Channels
The use of engineered nanopores as sensing elements for chemical and biological agents is a rapidly developing area. The distinct signatures of nanopore-nanoparticle lend themselve...
Bharatan Konnanath, Prasanna Sattigeri, Trupthi Ma...