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» Kinetic perturbations as robustness analysis tool for bioche...
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CDC
2009
IEEE
133views Control Systems» more  CDC 2009»
13 years 9 months ago
Kinetic perturbations as robustness analysis tool for biochemical reaction networks
— Models of biochemical reaction networks can be decomposed into a stoichiometric part and a kinetic part. The stoichiometric part describes the structural mass flows while the ...
Steffen Waldherr, Frank Allgöwer, Elling W. J...
BMCBI
2010
131views more  BMCBI 2010»
13 years 5 months ago
A comparison of approximation techniques for variance-based sensitivity analysis of biochemical reaction systems
Background: Sensitivity analysis is an indispensable tool for the analysis of complex systems. In a recent paper, we have introduced a thermodynamically consistent variance-based ...
Hong-Xuan Zhang, John Goutsias
BMCBI
2010
191views more  BMCBI 2010»
13 years 5 months ago
BiGG: a Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions
Background: Genome-scale metabolic reconstructions under the Constraint Based Reconstruction and Analysis (COBRA) framework are valuable tools for analyzing the metabolic capabili...
Jan Schellenberger, Junyoung O. Park, Tom M. Conra...
BMCBI
2006
179views more  BMCBI 2006»
13 years 4 months ago
Multiscale Hy3S: Hybrid stochastic simulation for supercomputers
Background: Stochastic simulation has become a useful tool to both study natural biological systems and design new synthetic ones. By capturing the intrinsic molecular fluctuation...
Howard Salis, Vassilios Sotiropoulos, Yiannis N. K...