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» LIMPIC: a computational method for the separation of protein...
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BMCBI
2007
135views more  BMCBI 2007»
13 years 4 months ago
LIMPIC: a computational method for the separation of protein MALDI-TOF-MS signals from noise
Background: Mass spectrometry protein profiling is a promising tool for biomarker discovery in clinical proteomics. However, the development of a reliable approach for the separat...
Dante Mantini, Francesca Petrucci, Damiana Pierago...
COMPLIFE
2006
Springer
13 years 8 months ago
Beating the Noise: New Statistical Methods for Detecting Signals in MALDI-TOF Spectra Below Noise Level
Background: The computer-assisted detection of small molecules by mass spectrometry in biological samples provides a snapshot of thousands of peptides, protein fragments and prote...
Tim O. F. Conrad, Alexander Leichtle, Andre Hageh&...
BMCBI
2007
166views more  BMCBI 2007»
13 years 4 months ago
PathFinder: mining signal transduction pathway segments from protein-protein interaction networks
Background: A Signal transduction pathway is the chain of processes by which a cell converts an extracellular signal into a response. In most unicellular organisms, the number of ...
Gürkan Bebek, Jiong Yang
RECOMB
2005
Springer
14 years 4 months ago
Comparison of Protein-Protein Interaction Confidence Assignment Schemes
Recent technological advances have enabled high-throughput measurements of protein-protein interactions in the cell, producing protein interaction networks for various species at a...
Silpa Suthram, Tomer Shlomi, Eytan Ruppin, Roded S...
RECOMB
2001
Springer
14 years 4 months ago
Geometric algorithms for the analysis of 2D-electrophoresis gels
In proteomics 2?dimensional gel electrophoresis (2?DE) is a separation technique for proteins. The resulting protein spots can be identified by either using picking robots and sub...
Alon Efrat, Frank Hoffmann, Klaus Kriegel, Christo...