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» MDGA: motif discovery using a genetic algorithm
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BMCBI
2010
124views more  BMCBI 2010»
13 years 5 months ago
The value of position-specific priors in motif discovery using MEME
Background: Position-specific priors have been shown to be a flexible and elegant way to extend the power of Gibbs sampler-based motif discovery algorithms. Information of many ty...
Timothy L. Bailey, Mikael Bodén, Tom Whitin...
BMCBI
2005
169views more  BMCBI 2005»
13 years 5 months ago
Genetic interaction motif finding by expectation maximization - a novel statistical model for inferring gene modules from synthe
Background: Synthetic lethality experiments identify pairs of genes with complementary function. More direct functional associations (for example greater probability of membership...
Yan Qi 0003, Ping Ye, Joel S. Bader
GECCO
2007
Springer
258views Optimization» more  GECCO 2007»
13 years 9 months ago
TFBS identification by position- and consensus-led genetic algorithm with local filtering
Identification of Transcription Factor Binding Site (TFBS) motifs in multiple DNA upstream sequences is important in understanding the mechanism of gene regulation. This identific...
Tak-Ming Chan, Kwong-Sak Leung, Kin-Hong Lee
GECCO
2005
Springer
162views Optimization» more  GECCO 2005»
13 years 11 months ago
Discovering biological motifs with genetic programming
Choosing the right representation for a problem is important. In this article we introduce a linear genetic programming approach for motif discovery in protein families, and we al...
Rolv Seehuus, Amund Tveit, Ole Edsberg
SAC
2004
ACM
13 years 11 months ago
Guiding motif discovery by iterative pattern refinement
In this paper, we demonstrate that the performance of a motif discovery algorithm can be significantly improved by embedding it into a novel framework that effectively guides the ...
Zhiping Wang, Mehmet M. Dalkilic, Sun Kim