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BMCBI
2008
131views more  BMCBI 2008»
8 years 8 months ago
Major copy proportion analysis of tumor samples using SNP arrays
Background: Single nucleotide polymorphisms (SNPs) are the most common genetic variations in the human genome and are useful as genomic markers. Oligonucleotide SNP microarrays ha...
Cheng Li, Rameen Beroukhim, Barbara A. Weir, Wendy...
BMCBI
2008
98views more  BMCBI 2008»
8 years 8 months ago
Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios
Background: Illumina Infinium whole genome genotyping (WGG) arrays are increasingly being applied in cancer genomics to study gene copy number alterations and allele-specific aber...
Johan Staaf, Johan Vallon-Christersson, David Lind...
BMCBI
2006
174views more  BMCBI 2006»
8 years 8 months ago
CARAT: A novel method for allelic detection of DNA copy number changes using high density oligonucleotide arrays
Background: DNA copy number alterations are one of the main characteristics of the cancer cell karyotype and can contribute to the complex phenotype of these cells. These alterati...
Jing Huang, Wen Wei, Joyce Chen, Jane Zhang, Guoyi...
BMCBI
2010
107views more  BMCBI 2010»
8 years 8 months ago
Conditional random pattern model for copy number aberration detection
Background: DNA copy number aberration (CNA) is very important in the pathogenesis of tumors and other diseases. For example, CNAs may result in suppression of anti-oncogenes and ...
Fuhai Li, Xiaobo Zhou, Wanting Huang, Chung-Che Ch...
BMCBI
2007
94views more  BMCBI 2007»
8 years 8 months ago
A Hidden Markov Model to estimate population mixture and allelic copy-numbers in cancers using Affymetrix SNP arrays
Background: Affymetrix SNP arrays can interrogate thousands of SNPs at the same time. This allows us to look at the genomic content of cancer cells and to investigate the underlyi...
Philippe Lamy, Claus L. Andersen, Lars Dyrskjot, N...
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