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WSC
1998
13 years 5 months ago
Modeling Cardiac Ion Channel Conductivity: Model Fitting via Simulation
We describe a Markov state model for a cloned potassium channel of the human heart ( 1KvLQTI ). The parameters of the model are determined by a least-squares fit of predicted vs. ...
John L. Maryak, Richard H. Smith, Raimond L. Winsl...
CMSB
2008
Springer
13 years 6 months ago
Formal Analysis of Abnormal Excitation in Cardiac Tissue
We present the Piecewise Linear Approximation Model of Ion Channel contribution (PLAMIC) to cardiac excitation. We use the PLAMIC model to conduct formal analysis of cardiac arrhyt...
Pei Ye, Radu Grosu, Scott A. Smolka, Emilia Entche...
TCBB
2011
12 years 11 months ago
Semi-Markov Models for Brownian Dynamics Permeation in Biological Ion Channels
—Constructing accurate computational models that explain how ions permeate through a biological ion channel is an important problem in biophysics and drug design. Brownian dynami...
Vikram Krishnamurthy, Kai Yiu Luk
ICIP
2007
IEEE
14 years 6 months ago
Joint Localization and Parameter Estimation for Localized Calcium Release Events in Video Microscopy
This paper addresses modeling and inference for localized calcium release events observed in cardiac muscle tissue known as sparks, a recently discovered and little-understood phe...
Benjamin P. Olding, Patrick J. Wolfe
SG
2007
Springer
13 years 10 months ago
A Sketch-Based Interface for Modeling Myocardial Fiber Orientation
: We propose a sketch-based interface for modeling the myocardial fiber orientation required in the electrophysiological simulation of the heart, especially the ventricles. The use...
Kenshi Takayama, Takeo Igarashi, Ryo Haraguchi, Ka...