We describe a Markov state model for a cloned potassium channel of the human heart ( 1KvLQTI ). The parameters of the model are determined by a least-squares fit of predicted vs. ...
John L. Maryak, Richard H. Smith, Raimond L. Winsl...
We present the Piecewise Linear Approximation Model of Ion Channel contribution (PLAMIC) to cardiac excitation. We use the PLAMIC model to conduct formal analysis of cardiac arrhyt...
Pei Ye, Radu Grosu, Scott A. Smolka, Emilia Entche...
—Constructing accurate computational models that explain how ions permeate through a biological ion channel is an important problem in biophysics and drug design. Brownian dynami...
This paper addresses modeling and inference for localized calcium release events observed in cardiac muscle tissue known as sparks, a recently discovered and little-understood phe...
: We propose a sketch-based interface for modeling the myocardial fiber orientation required in the electrophysiological simulation of the heart, especially the ventricles. The use...