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BMCBI
2007
107views more  BMCBI 2007»
13 years 5 months ago
Prediction of potential drug targets based on simple sequence properties
Background: During the past decades, research and development in drug discovery have attracted much attention and efforts. However, only 324 drug targets are known for clinical dr...
Qingliang Li, Luhua Lai
BMCBI
2008
170views more  BMCBI 2008»
13 years 5 months ago
A genetic approach for building different alphabets for peptide and protein classification
Background: In this paper, it is proposed an optimization approach for producing reduced alphabets for peptide classification, using a Genetic Algorithm. The classification task i...
Loris Nanni, Alessandra Lumini
IJON
2010
178views more  IJON 2010»
13 years 4 months ago
An empirical study of two typical locality preserving linear discriminant analysis methods
: Laplacian Linear Discriminant Analysis (LapLDA) and Semi-supervised Discriminant Analysis (SDA) are two recently proposed LDA methods. They are developed independently with the a...
Lishan Qiao, Limei Zhang, Songcan Chen
STOC
2010
ACM
168views Algorithms» more  STOC 2010»
14 years 3 months ago
Non-commutative circuits and the sum-of-squares problem
We initiate a direction for proving lower bounds on the size of non-commutative arithmetic circuits. This direction is based on a connection between lower bounds on the size of no...
Pavel Hrubes, Avi Wigderson and Amir Yehudayoff
STOC
2007
ACM
134views Algorithms» more  STOC 2007»
14 years 6 months ago
Hardness of routing with congestion in directed graphs
Given as input a directed graph on N vertices and a set of source-destination pairs, we study the problem of routing the maximum possible number of source-destination pairs on pat...
Julia Chuzhoy, Venkatesan Guruswami, Sanjeev Khann...