Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
Background: To standardize gene product descriptions, a formal vocabulary defined as the Gene Ontology (GO) has been developed. GO terms have been categorized into biological proc...
Abstract. We present a multigrid algorithm for the solution of distributed parameter inverse problems constrained by variable-coefficient linear parabolic partial differential equa...
Background: Discovering approximately repeated patterns, or motifs, in biological sequences is an important and widely-studied problem in computational molecular biology. Most fre...
PDE surfaces, whose behavior is governed by Partial Differential Equations (PDEs), have demonstrated many modeling advantages in surface blending, free-form surface modeling, and ...