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BMCBI
2008
84views more  BMCBI 2008»
13 years 5 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
BMCBI
2005
112views more  BMCBI 2005»
13 years 5 months ago
Integration of the Gene Ontology into an object-oriented architecture
Background: To standardize gene product descriptions, a formal vocabulary defined as the Gene Ontology (GO) has been developed. GO terms have been categorized into biological proc...
Daniel Shegogue, W. Jim Zheng
SIAMSC
2008
179views more  SIAMSC 2008»
13 years 5 months ago
Multigrid Algorithms for Inverse Problems with Linear Parabolic PDE Constraints
Abstract. We present a multigrid algorithm for the solution of distributed parameter inverse problems constrained by variable-coefficient linear parabolic partial differential equa...
Santi S. Adavani, George Biros
ALMOB
2006
138views more  ALMOB 2006»
13 years 5 months ago
A combinatorial optimization approach for diverse motif finding applications
Background: Discovering approximately repeated patterns, or motifs, in biological sequences is an important and widely-studied problem in computational molecular biology. Most fre...
Elena Zaslavsky, Mona Singh
PG
2000
IEEE
13 years 10 months ago
Dynamic PDE Surfaces with Flexible and General Geometric Constraints
PDE surfaces, whose behavior is governed by Partial Differential Equations (PDEs), have demonstrated many modeling advantages in surface blending, free-form surface modeling, and ...
Haixia Du, Hong Qin