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BMCBI
2006
137views more  BMCBI 2006»
13 years 6 months ago
A maximum likelihood framework for protein design
Background: The aim of protein design is to predict amino-acid sequences compatible with a given target structure. Traditionally envisioned as a purely thermodynamic question, thi...
Claudia L. Kleinman, Nicolas Rodrigue, Céci...
SIGADA
1999
Springer
13 years 10 months ago
Towards a distributed object-oriented propagation model using Ada95
Representing interdependencies between the objects of an object-oriented software application requires designtime mechanisms for specifying object interrelationships, as well as s...
Donald M. Needham, Steven A. Demurjian, Thomas J. ...
POPL
2011
ACM
12 years 8 months ago
Pick your contexts well: understanding object-sensitivity
ensitivity has emerged as an excellent context abstraction for points-to analysis in object-oriented languages. Despite its practical success, however, object-sensitivity is poorl...
Yannis Smaragdakis, Martin Bravenboer, Ondrej Lhot...
SCFBM
2008
87views more  SCFBM 2008»
13 years 5 months ago
Analysis by siRNA_profile program displays novel thermodynamic characteristics of highly functional siRNA molecules
Objective: Here we report the improved results of a new siRNA design program and analysis tool called siRNA_profile that reveals an additional criterion for bioinformatic search o...
Pirkko Muhonen, Ranga N. Parthasarathy, Anthony J....
WSCG
2004
151views more  WSCG 2004»
13 years 7 months ago
Inserting G1 Discontinuities into Free-form Features for Aesthetic Design
Free form shapes are often used to fulfil both aesthetic and design constraints applied to parametric models currently adopted in CAD environments. Up to now, designers and engine...
Vincent Cheutet, Jean-Philippe Pernot, Jean-Claude...