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    BMCBI
    2008
    90views more  BMCBI 2008»
    Genome-scale study of the importance of binding site context for transcription factor binding and gene regulation
    13 years 5 months ago
    Genome-scale study of the importance of binding site context for transcription factor binding and gene regulation
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    Background: The rate of mRNA transcription is controlled by transcription factors that bind to specific DNA motifs in promoter regions upstream of protein coding genes. Recent res...
    Jakub Orzechowski Westholm, Feifei Xu, Hans Ronne,...
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    BMCBI
    2010
    148views more  BMCBI 2010»
    Applying unmixing to gene expression data for tumor phylogeny inference
    13 years 5 months ago
    Applying unmixing to gene expression data for tumor phylogeny inference
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    Background: While in principle a seemingly infinite variety of combinations of mutations could result in tumor development, in practice it appears that most human cancers fall int...
    Russell Schwartz, Stanley Shackney
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    BMCBI
    2007
    182views more  BMCBI 2007»
    Identifying regulatory targets of cell cycle transcription factors using gene expression and ChIP-chip data
    13 years 5 months ago
    Identifying regulatory targets of cell cycle transcription factors using gene expression and ChIP-chip data
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    Background: ChIP-chip data, which indicate binding of transcription factors (TFs) to DNA regions in vivo, are widely used to reconstruct transcriptional regulatory networks. Howev...
    Wei-Sheng Wu, Wen-Hsiung Li, Bor-Sen Chen
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    BMCBI
    2007
    123views more  BMCBI 2007»
    PedGenie: meta genetic association testing in mixed family and case-control designs
    13 years 5 months ago
    PedGenie: meta genetic association testing in mixed family and case-control designs
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    Background-: PedGenie software, introduced in 2006, includes genetic association testing of cases and controls that may be independent or related (nuclear families or extended ped...
    Karen Curtin, Jathine Wong, Kristina Allen-Brady, ...
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    BMCBI
    2006
    88views more  BMCBI 2006»
    Effect of various normalization methods on Applied Biosystems expression array system data
    13 years 5 months ago
    Effect of various normalization methods on Applied Biosystems expression array system data
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    Background: DNA microarray technology provides a powerful tool for characterizing gene expression on a genome scale. While the technology has been widely used in discovery-based m...
    Catalin C. Barbacioru, Yulei Wang, Roger D. Canale...
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