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» On the Brittleness of Evolutionary Algorithms
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BMCBI
2006
156views more  BMCBI 2006»
13 years 5 months ago
Score-based prediction of genomic islands in prokaryotic genomes using hidden Markov models
Background: Horizontal gene transfer (HGT) is considered a strong evolutionary force shaping the content of microbial genomes in a substantial manner. It is the difference in spee...
Stephan Waack, Oliver Keller, Roman Asper, Thomas ...
BMCBI
2006
150views more  BMCBI 2006»
13 years 5 months ago
Protein structure similarity from principle component correlation analysis
Background: Owing to rapid expansion of protein structure databases in recent years, methods of structure comparison are becoming increasingly effective and important in revealing...
Xiaobo Zhou, James Chou, Stephen T. C. Wong
BMCBI
2006
129views more  BMCBI 2006»
13 years 5 months ago
Independent Component Analysis-motivated Approach to Classificatory Decomposition of Cortical Evoked Potentials
Background: Independent Component Analysis (ICA) proves to be useful in the analysis of neural activity, as it allows for identification of distinct sources of activity. Applied t...
Tomasz G. Smolinski, Roger Buchanan, Grzegorz M. B...
BMCBI
2006
130views more  BMCBI 2006»
13 years 5 months ago
MicroTar: predicting microRNA targets from RNA duplexes
Background: The accurate prediction of a comprehensive set of messenger RNAs (targets) regulated by animal microRNAs (miRNAs) remains an open problem. In particular, the predictio...
Rahul Thadani, Martti T. Tammi
BMCBI
2006
103views more  BMCBI 2006»
13 years 5 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...