Background: ChIP-chip data, which indicate binding of transcription factors (TFs) to DNA regions in vivo, are widely used to reconstruct transcriptional regulatory networks. Howev...
Background: Network Component Analysis (NCA) has shown its effectiveness in discovering regulators and inferring transcription factor activities (TFAs) when both microarray data a...
Chen Wang, Jianhua Xuan, Li Chen, Po Zhao, Yue Wan...
Background: With the abundant information produced by microarray technology, various approaches have been proposed to infer transcriptional regulatory networks. However, few appro...
Grace S. Shieh, Chung-Ming Chen, Ching-Yun Yu, Jui...
Background: A complete understanding of the regulatory mechanisms of gene expression is the next important issue of genomics. Many bioinformaticians have developed methods and alg...
Abstract. In this paper we address the problem of finding gene regulatory networks from experimental DNA microarray data. We introduce enhancements to an Evolutionary Algorithm op...
Christian Spieth, Felix Streichert, Nora Speer, An...