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BMCBI
2007
166views more  BMCBI 2007»
13 years 5 months ago
PathFinder: mining signal transduction pathway segments from protein-protein interaction networks
Background: A Signal transduction pathway is the chain of processes by which a cell converts an extracellular signal into a response. In most unicellular organisms, the number of ...
Gürkan Bebek, Jiong Yang
BMCBI
2010
201views more  BMCBI 2010»
13 years 5 months ago
Analysis of X-ray Structures of Matrix Metalloproteinases via Chaotic Map Clustering
Background: Matrix metalloproteinases (MMPs) are well-known biological targets implicated in tumour progression, homeostatic regulation, innate immunity, impaired delivery of pro-...
Ilenia Giangreco, Orazio Nicolotti, Angelo Carotti...
BMCBI
2006
122views more  BMCBI 2006»
13 years 5 months ago
A multivariate prediction model for microarray cross-hybridization
Background: Expression microarray analysis is one of the most popular molecular diagnostic techniques in the post-genomic era. However, this technique faces the fundamental proble...
Yian A. Chen, Cheng-Chung Chou, Xinghua Lu, Elizab...
BMCBI
2006
129views more  BMCBI 2006»
13 years 5 months ago
Functional clustering of yeast proteins from the protein-protein interaction network
Background: The abundant data available for protein interaction networks have not yet been fully understood. New types of analyses are needed to reveal organizational principles o...
Taner Z. Sen, Andrzej Kloczkowski, Robert L. Jerni...
BMCBI
2007
115views more  BMCBI 2007»
13 years 5 months ago
Local comparison of protein structures highlights cases of convergent evolution in analogous functional sites
Background: We performed an exhaustive search for local structural similarities in an ensemble of non-redundant protein functional sites. With the purpose of finding new examples ...
Gabriele Ausiello, Daniele Peluso, Allegra Via, Ma...