4 search results - page 1 / 1 » Optimizing amino acid substitution matrices with a local ali... |
BMCBI
2006
13 years 5 months ago
2006
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...
LION
2009
Springer
13 years 12 months ago
2009
Springer
Abstract. Substitution matrices are at the heart of Bioinformatics: sequence alignment, database search, phylogenetic inference, protein family classi cation are based on Blosum, P...
BMCBI
2008
13 years 5 months ago
2008
Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...
BMCBI
2008
13 years 5 months ago
2008
Background: Classification of protein sequences is a central problem in computational biology. Currently, among computational methods discriminative kernel-based approaches provid...