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» Polymorphic Delimited Continuations
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BMCBI
2010
89views more  BMCBI 2010»
13 years 5 months ago
Spatial normalization improves the quality of genotype calling for Affymetrix SNP 6.0 arrays
Background: Microarray measurements are susceptible to a variety of experimental artifacts, some of which give rise to systematic biases that are spatially dependent in a unique w...
High-Seng Chai, Terry M. Therneau, Kent R. Bailey,...
BMCBI
2010
151views more  BMCBI 2010»
13 years 5 months ago
CCRaVAT and QuTie - enabling analysis of rare variants in large-scale case control and quantitative trait association studies
Background: Genome-wide association studies have been successful in finding common variants influencing common traits. However, these associations only account for a fraction of t...
Robert Lawrence, Aaron G. Day-Williams, Katherine ...
BMCBI
2007
103views more  BMCBI 2007»
13 years 5 months ago
eQTL Viewer: visualizing how sequence variation affects genome-wide transcription
Background: Expression Quantitative Trait Locus (eQTL) mapping methods have been used to identify the genetic basis of gene expression variations. To map eQTL, thousands of expres...
Wei Zou, David L. Aylor, Zhao-Bang Zeng
BMCBI
2006
116views more  BMCBI 2006»
13 years 4 months ago
Cluster analysis for DNA methylation profiles having a detection threshold
Background: DNA methylation, a molecular feature used to investigate tumor heterogeneity, can be measured on many genomic regions using the MethyLight technology. Due to the combi...
Paul Marjoram, Jing Chang, Peter W. Laird, Kimberl...
DTJ
1998
171views more  DTJ 1998»
13 years 4 months ago
Measurement and Analysis of C and C++ Performance
ir increasing use of abstraction, modularity, delayed binding, polymorphism, and source reuse, especially when these attributes are used in combination. Modern processor architectu...
Hemant G. Rotithor, Kevin W. Harris, Mark W. Davis