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BMCBI
2010
167views more  BMCBI 2010»
13 years 5 months ago
Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies
Background: Knowledge of transcription factor-DNA binding patterns is crucial for understanding gene transcription. Numerous DNA-binding proteins are annotated as transcription fa...
Denitsa Alamanova, Philip Stegmaier, Alexander E. ...
BMCBI
2008
90views more  BMCBI 2008»
13 years 5 months ago
Genome-scale study of the importance of binding site context for transcription factor binding and gene regulation
Background: The rate of mRNA transcription is controlled by transcription factors that bind to specific DNA motifs in promoter regions upstream of protein coding genes. Recent res...
Jakub Orzechowski Westholm, Feifei Xu, Hans Ronne,...
GCB
2004
Springer
113views Biometrics» more  GCB 2004»
13 years 10 months ago
Feature Based Representation and Detection of Transcription Factor Binding Sites
: The prediction of transcription factor binding sites is an important problem, since it reveals information about the transcriptional regulation of genes. A commonly used represen...
Rainer Pudimat, Ernst Günter Schukat-Talamazz...
BMCBI
2005
104views more  BMCBI 2005»
13 years 4 months ago
Scoring functions for transcription factor binding site prediction
Background: Transcription factor binding site (TFBS) prediction is a difficult problem, which requires a good scoring function to discriminate between real binding sites and backg...
Markus T. Friberg, Peter von Rohr, Gaston H. Gonne...
BMCBI
2010
122views more  BMCBI 2010»
13 years 5 months ago
Simultaneous prediction of transcription factor binding sites in a group of prokaryotic genomes
Background: Our current understanding of transcription factor binding sites (TFBSs) in sequenced prokaryotic genomes is very limited due to the lack of an accurate and efficient c...
Shaoqiang Zhang, Shan Li, Phuc T. Pham, Zhengchang...