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» Quantifying robustness of biochemical network models
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BMCBI
2002
75views more  BMCBI 2002»
13 years 4 months ago
Quantifying robustness of biochemical network models
Background: Robustness of mathematical models of biochemical networks is important for validation purposes and can be used as a means of selecting between different competing mode...
Lan Ma, Pablo A. Iglesias
CDC
2009
IEEE
133views Control Systems» more  CDC 2009»
13 years 9 months ago
Kinetic perturbations as robustness analysis tool for biochemical reaction networks
— Models of biochemical reaction networks can be decomposed into a stoichiometric part and a kinetic part. The stoichiometric part describes the structural mass flows while the ...
Steffen Waldherr, Frank Allgöwer, Elling W. J...
BIOINFORMATICS
2006
106views more  BIOINFORMATICS 2006»
13 years 4 months ago
Identification of biochemical networks by S-tree based genetic programming
Motivation: Most previous approaches to model biochemical networks havefocusedeither on the characterization of a networkstructurewith a number of components or on the estimation ...
Dong-Yeon Cho, Kwang-Hyun Cho, Byoung-Tak Zhang
BMCBI
2010
131views more  BMCBI 2010»
13 years 5 months ago
A comparison of approximation techniques for variance-based sensitivity analysis of biochemical reaction systems
Background: Sensitivity analysis is an indispensable tool for the analysis of complex systems. In a recent paper, we have introduced a thermodynamically consistent variance-based ...
Hong-Xuan Zhang, John Goutsias
CMSB
2009
Springer
13 years 11 months ago
Modelling Biological Clocks with Bio-PEPA: Stochasticity and Robustness for the Neurospora crassa Circadian Network
Circadian clocks are biochemical networks, present in nearly all living organisms, whose function is to regulate the expression of specific mRNAs and proteins to synchronise rhyth...
Ozgur E. Akman, Federica Ciocchetta, Andrea Degasp...