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» Quantitative analysis of EGR proteins binding to DNA: assess...
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BMCBI
2010
110views more  BMCBI 2010»
13 years 5 months ago
On the use of resampling tests for evaluating statistical significance of binding-site co-occurrence
Background: In eukaryotes, most DNA-binding proteins exert their action as members of large effector complexes. The presence of these complexes are revealed in high-throughput gen...
David S. Huen, Steven Russell
BMCBI
2008
136views more  BMCBI 2008»
13 years 5 months ago
GPAT: Retrieval of genomic annotation from large genomic position datasets
Background: Recent genome wide transcription factor binding site or chromatin modification mapping analysis techniques, such as chromatin immunoprecipitation (ChIP) linked to DNA ...
Arnaud Krebs, Mattia Frontini, Làszlò...
BMCBI
2005
147views more  BMCBI 2005»
13 years 5 months ago
GATA: a graphic alignment tool for comparative sequence analysis
Background: Several problems exist with current methods used to align DNA sequences for comparative sequence analysis. Most dynamic programming algorithms assume that conserved se...
David A. Nix, Michael B. Eisen
BMCBI
2008
184views more  BMCBI 2008»
13 years 5 months ago
"TOF2H": A precision toolbox for rapid, high density/high coverage hydrogen-deuterium exchange mass spectrometry via an LC-MALDI
Background: Protein-amide proton hydrogen-deuterium exchange (HDX) is used to investigate protein conformation, conformational changes and surface binding sites for other molecule...
Pornpat Nikamanon, Elroy Pun, Wayne Chou, Marek D....
BMCBI
2006
134views more  BMCBI 2006»
13 years 5 months ago
Application of machine learning in SNP discovery
Background: Single nucleotide polymorphisms (SNP) constitute more than 90% of the genetic variation, and hence can account for most trait differences among individuals in a given ...
Lakshmi K. Matukumalli, John J. Grefenstette, Davi...