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BMCBI
2007
120views more  BMCBI 2007»
13 years 4 months ago
Quantitative sequence-function relationships in proteins based on gene ontology
Background: The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs share function...
Vineet Sangar, Daniel J. Blankenberg, Naomi Altman...
BMCBI
2006
207views more  BMCBI 2006»
13 years 4 months ago
A new measure for functional similarity of gene products based on Gene Ontology
Background: Gene Ontology (GO) is a standard vocabulary of functional terms and allows for coherent annotation of gene products. These annotations provide a basis for new methods ...
Andreas Schlicker, Francisco S. Domingues, Jö...
BMCBI
2006
167views more  BMCBI 2006»
13 years 4 months ago
GOurmet: A tool for quantitative comparison and visualization of gene expression profiles based on gene ontology (GO) distributi
Background: The ever-expanding population of gene expression profiles (EPs) from specified cells and tissues under a variety of experimental conditions is an important but difficu...
Jason M. Doherty, Lynn K. Carmichael, Jason C. Mil...
BMCBI
2010
160views more  BMCBI 2010»
13 years 4 months ago
Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53
Background: The availability of various "omics" datasets creates a prospect of performing the study of genomewide genetic regulatory networks. However, one of the major ...
Junbai Wang, Tianhai Tian
BMCBI
2007
168views more  BMCBI 2007»
13 years 4 months ago
Automatic extraction of gene ontology annotation and its correlation with clusters in protein networks
Background: Uncovering cellular roles of a protein is a task of tremendous importance and complexity that requires dedicated experimental work as well as often sophisticated data ...
Nikolai Daraselia, Anton Yuryev, Sergei Egorov, Il...