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» Quantitative systems-level determinants of drug targets
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BMCBI
2008
115views more  BMCBI 2008»
13 years 5 months ago
Quantitative systems-level determinants of drug targets
ent> <title> <p>Highlights from the Fourth International Society for Computational Biology (ISCB) Student Council Symposium</p> </title> <editor>Lu...
Lixia Yao, Andrey Rzhetsky
BMCBI
2011
12 years 11 months ago
A theoretical entropy score as a single value to express inhibitor selectivity
Background: Designing maximally selective ligands that act on individual targets is the dominant paradigm in drug discovery. Poor selectivity can underlie toxicity and side effect...
Joost C. M. Uitdehaag, Guido J. R. Zaman