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BMCBI
2008
93views more  BMCBI 2008»
13 years 5 months ago
Ranking single nucleotide polymorphisms by potential deleterious effects
Identifying single nucleotide polymorphisms (SNPs) that are responsible for common and complex diseases such as cancer is of major interest in current molecular epidemiology. Howe...
Phil Hyoun Lee, Hagit Shatkay
BMCBI
2006
152views more  BMCBI 2006»
13 years 4 months ago
Predicting deleterious nsSNPs: an analysis of sequence and structural attributes
Background: There has been an explosion in the number of single nucleotide polymorphisms (SNPs) within public databases. In this study we focused on non-synonymous protein coding ...
Richard J. B. Dobson, Patricia B. Munroe, Mark J. ...
BMCBI
2007
127views more  BMCBI 2007»
13 years 4 months ago
Predicting the phenotypic effects of non-synonymous single nucleotide polymorphisms based on support vector machines
Background: Human genetic variations primarily result from single nucleotide polymorphisms (SNPs) that occur approximately every 1000 bases in the overall human population. The no...
Jian Tian, Ningfeng Wu, Xuexia Guo, Jun Guo, Juhua...
BMCBI
2008
151views more  BMCBI 2008»
13 years 5 months ago
An integrated database-pipeline system for studying single nucleotide polymorphisms and diseases
Background: Studies on the relationship between disease and genetic variations such as single nucleotide polymorphisms (SNPs) are important. Genetic variations can cause disease b...
Jin Ok Yang, Sohyun Hwang, Jeongsu Oh, Jong Bhak, ...
NAR
2006
88views more  NAR 2006»
13 years 4 months ago
PupaSuite: finding functional single nucleotide polymorphisms for large-scale genotyping purposes
We have developed a web tool, PupaSuite, for the selection of single nucleotide polymorphisms (SNPs) with potential phenotypic effect, specifically oriented to help in the design ...
Lucía Conde, Juan M. Vaquerizas, Hern&aacut...