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BMCBI
2011
12 years 12 months ago
A theoretical entropy score as a single value to express inhibitor selectivity
Background: Designing maximally selective ligands that act on individual targets is the dominant paradigm in drug discovery. Poor selectivity can underlie toxicity and side effect...
Joost C. M. Uitdehaag, Guido J. R. Zaman
ICDE
2012
IEEE
203views Database» more  ICDE 2012»
11 years 7 months ago
Parameter-Free Determination of Distance Thresholds for Metric Distance Constraints
—The importance of introducing distance constraints to data dependencies, such as differential dependencies (DDs) [28], has recently been recognized. The metric distance constrai...
Shaoxu Song, Lei Chen 0002, Hong Cheng
BMCBI
2005
108views more  BMCBI 2005»
13 years 5 months ago
The modeled structure of the RNA dependent RNA polymerase of GBV-C Virus suggests a role for motif E in Flaviviridae RNA polymer
Background: The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the replication process, and t...
François Ferron, Cécile Bussetta, H&...