Background: Designing maximally selective ligands that act on individual targets is the dominant paradigm in drug discovery. Poor selectivity can underlie toxicity and side effect...
—The importance of introducing distance constraints to data dependencies, such as differential dependencies (DDs) [28], has recently been recognized. The metric distance constrai...
Background: The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the replication process, and t...