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BMCBI
2008
135views more  BMCBI 2008»
13 years 5 months ago
Identification of a small optimal subset of CpG sites as bio-markers from high-throughput DNA methylation profiles
Background: DNA methylation patterns have been shown to significantly correlate with different tissue types and disease states. High-throughput methylation arrays enable large-sca...
Hailong Meng, Edward Lenn Murrelle, Guoya Li
BMCBI
2006
116views more  BMCBI 2006»
13 years 5 months ago
Cluster analysis for DNA methylation profiles having a detection threshold
Background: DNA methylation, a molecular feature used to investigate tumor heterogeneity, can be measured on many genomic regions using the MethyLight technology. Due to the combi...
Paul Marjoram, Jing Chang, Peter W. Laird, Kimberl...
BMCBI
2007
120views more  BMCBI 2007»
13 years 5 months ago
Transcript-based redefinition of grouped oligonucleotide probe sets using AceView: High-resolution annotation for microarrays
Background: Extracting biological information from high-density Affymetrix arrays is a multi-step process that begins with the accurate annotation of microarray probes. Shortfalls...
Jun Lu, Joseph C. Lee, Marc L. Salit, Margaret C. ...
BMCBI
2007
136views more  BMCBI 2007»
13 years 5 months ago
Prediction of tissue-specific cis-regulatory modules using Bayesian networks and regression trees
Background: In vertebrates, a large part of gene transcriptional regulation is operated by cisregulatory modules. These modules are believed to be regulating much of the tissue-sp...
Xiaoyu Chen, Mathieu Blanchette
BMCBI
2011
13 years 8 days ago
The dChip survival analysis module for microarray data
Background: Genome-wide expression signatures are emerging as potential marker for overall survival and disease recurrence risk as evidenced by recent commercialization of gene ex...
Samir B. Amin, Parantu K. Shah, Aimin Yan, Sophia ...