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JORS
2011
67views more  JORS 2011»
12 years 11 months ago
Robust parameter design optimization of simulation experiments using stochastic perturbation methods
Stochastic perturbation methods can be applied to problems for which either the objective function is represented analytically, or the objective function is the result of a simula...
A. K. Miranda, E. Del Castillo
BMCBI
2006
179views more  BMCBI 2006»
13 years 4 months ago
Multiscale Hy3S: Hybrid stochastic simulation for supercomputers
Background: Stochastic simulation has become a useful tool to both study natural biological systems and design new synthetic ones. By capturing the intrinsic molecular fluctuation...
Howard Salis, Vassilios Sotiropoulos, Yiannis N. K...
WSC
2007
13 years 7 months ago
Stochastic trust region gradient-free method (strong): a new response-surface-based algorithm in simulation optimization
Response Surface Methodology (RSM) is a metamodelbased optimization method. Its strategy is to explore small subregions of the parameter space in succession instead of attempting ...
Kuo-Hao Chang, L. Jeff Hong, Hong Wan
TSMC
2010
12 years 11 months ago
On Robust Stability of Stochastic Genetic Regulatory Networks With Time Delays: A Delay Fractioning Approach
Robust stability serves as an important regulation mechanism in system biology and synthetic biology. In this paper, the robust stability analysis problem is investigated for a cla...
Yao Wang, Zidong Wang, Jinling Liang
INFORMS
2000
128views more  INFORMS 2000»
13 years 4 months ago
A Revised Simplex Search Procedure for Stochastic Simulation Response Surface Optimization
We develop a variant of the Nelder-Mead (NM) simplex search procedure for stochastic simulation optimization that is designed to avoid many of the weaknesses encumbering such dire...
David G. Humphrey, James R. Wilson