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» Sequence Alignment as a Database Technology Challenge
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SIGMOD
2005
ACM
169views Database» more  SIGMOD 2005»
13 years 11 months ago
Data and metadata management in service-oriented architectures: some open challenges
Over the last decade, the role of information technology in enterprises has been transforming from one of providing automation services to one of enabling business innovation. ITâ...
Vishal Sikka
TCBB
2008
95views more  TCBB 2008»
13 years 6 months ago
Solving the Problem of Trans-Genomic Query with Alignment Tables
Abstract-- The trans-genomic query (TGQ) problem -- enabling the free query of biological information, even across genomes -- is a central challenge facing bioinformatics. Solution...
Douglas Stott Parker Jr., Ruey-Lung Hsiao, Yi Xing...
BMCBI
2007
142views more  BMCBI 2007»
13 years 6 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
BMCBI
2010
132views more  BMCBI 2010»
13 years 6 months ago
Data structures and compression algorithms for high-throughput sequencing technologies
Background: High-throughput sequencing (HTS) technologies play important roles in the life sciences by allowing the rapid parallel sequencing of very large numbers of relatively s...
Kenny Daily, Paul Rigor, Scott Christley, Xiaohui ...
SC
2009
ACM
13 years 10 months ago
Cloud technologies for bioinformatics applications
Executing large number of independent tasks or tasks that perform minimal inter-task communication in parallel is a common requirement in many domains. In this paper, we present o...
Xiaohong Qiu, Jaliya Ekanayake, Scott Beason, Thil...