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BMCBI
2006
103views more  BMCBI 2006»
13 years 5 months ago
Domain-based small molecule binding site annotation
Background: Accurate small molecule binding site information for a protein can facilitate studies in drug docking, drug discovery and function prediction, but small molecule bindi...
Kevin A. Snyder, Howard J. Feldman, Michel Dumonti...
BMCBI
2008
97views more  BMCBI 2008»
13 years 5 months ago
SiteSeek: Post-translational modification analysis using adaptive locality-effective kernel methods and new profiles
Background: Post-translational modifications have a substantial influence on the structure and functions of protein. Post-translational phosphorylation is one of the most common m...
Paul D. Yoo, Yung Shwen Ho, Bing Bing Zhou, Albert...
BMCBI
2006
108views more  BMCBI 2006»
13 years 5 months ago
Gene function classification using Bayesian models with hierarchy-based priors
We investigate the application of hierarchical classification schemes to the annotation of gene function based on several characteristics of protein sequences including phylogenic ...
Babak Shahbaba, Radford M. Neal
CEC
2009
IEEE
13 years 10 months ago
A novel EDAs based method for HP model protein folding
— The protein structure prediction (PSP) problem is one of the most important problems in computational biology. This paper proposes a novel Estimation of Distribution Algorithms...
Benhui Chen, Long Li, Jinglu Hu
BMCBI
2006
103views more  BMCBI 2006»
13 years 5 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...