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» Settling the Intractability of Multiple Alignment
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ISAAC
2003
Springer
70views Algorithms» more  ISAAC 2003»
13 years 10 months ago
Settling the Intractability of Multiple Alignment
In this paper some of the most fundamental problems in computational biology are proved intractable. The following problems are shown NP-hard for all binary or larger alphabets und...
Isaac Elias
CPM
2006
Springer
145views Combinatorics» more  CPM 2006»
13 years 9 months ago
Approximation of RNA Multiple Structural Alignment
Abstract. In the context of non-coding RNA (ncRNA) multiple structural alignment, Davydov and Batzoglou introduced in [7] the problem of finding the largest nested linear graph tha...
Marcin Kubica, Romeo Rizzi, Stéphane Vialet...
HPDC
2010
IEEE
13 years 6 months ago
Modeling sequence and function similarity between proteins for protein functional annotation
A common task in biological research is to predict function for proteins by comparing sequences between proteins of known and unknown function. This is often done using pair-wise ...
Roger Higdon, Brenton Louie, Eugene Kolker
EVOW
2008
Springer
13 years 7 months ago
Divide, Align and Full-Search for Discovering Conserved Protein Complexes
Advances in modern technologies for measuring protein-protein interaction (PPI) has boosted research in PPI networks analysis and comparison. One of the challenging problems in com...
Pavol Jancura, Jaap Heringa, Elena Marchiori
GECCO
2007
Springer
258views Optimization» more  GECCO 2007»
13 years 9 months ago
TFBS identification by position- and consensus-led genetic algorithm with local filtering
Identification of Transcription Factor Binding Site (TFBS) motifs in multiple DNA upstream sequences is important in understanding the mechanism of gene regulation. This identific...
Tak-Ming Chan, Kwong-Sak Leung, Kin-Hong Lee